Thanks for the ideas guys.
Grizzlydave, I'm assuming you mean a register, high and low, on the same duct in the wall?
Birdhunter1, I'm adding an extra plate at the bottom of the walls and putting pex right on the floor, then fill the 1.5" bottom plate with gyp crete.
Hizoot, The house is about 1800 sf. The main great room looks like your typical tall "A" frame running N to S with high cathedral ceilings and two small bedrooms with loft overhead at the north end of the room. Off of each side ( east & west ) will be "wings". One will be the master bedroom, the other kit/dinning/utility etc.
Would a centralized return tend to favor the great room?