Is using GLP-1 weight loss programs like the ones offered by MEDVi actually safe for long‑term use?

[jyoutz]

10,000 steps of just walking can burn 500 calories. Per day, that's a pound per week. 52 pounds in a year... Not working out, WALKING

Health is holistic. When garden season begins, I lose 10 pounds in 6 weeks. Just because I'm in the garden working.

You can eat whatever you want, if you balance it with moving your body

I agree with that for maintaining body weight, but walking isn’t going to do much for weight reduction alone.

 

[mark in portugal]

Excess weight is a result of overeating.
Walking is good; I walk an hour every morning (I have the luxury of time).

Like all exercise, it increases the appetite.
Weight control is the result of appetite control.
If you can exercise and control your appetite, then you can also NOT exercise and control your appetite.
Exercise is great; but it has little to do with weight loss.

If you want to lose weight, seriously, just don't eat.
My regime is one one piece of fruit for lunch, one slice of bread (plain) for dinner.
Result; a bit over a pound a day goes away. Yes, it hurts. Yes, it's difficult.
But; after two or three weeks, the job is done. IF I can control my appetite thereafter, I don't gain it back too quickly.

The new drugs, Ozempic etc, lower the appetite.
I'm not using any; I will if I need to though.

 

[RandyT]

10,000 steps of just walking can burn 500 calories. Per day, that's a pound per week. 52 pounds in a year... Not working out, WALKING

Health is holistic. When garden season begins, I lose 10 pounds in 6 weeks. Just because I'm in the garden working.

You can eat whatever you want, if you balance it with moving your body

I agree with that for maintaining body weight, but walking isn’t going to do much for weight reduction alone.

So lets put this into true perspective. For the overweight person to achieve this it would be their normal daily activities + 10,000 steps.

 

[Torvy]

The Adkins diet was mostly meat; what I said was meat, eggs, and vegetables primarily. You can also add some high fiber carbs such as beans and full grains such as brown rice and oats, just not a lot of carbs. More of a low carb diet instead of no carbs. It can be healthy and sustainable.

Dr Atkins was a Cardiologist. Wife and I started the diet back in 2000 or so. Used Dr. Atkins' book.

In addition to lean meats, he absolutely advocated for high-fiber, low-sugar fruits and vegetables and other protein sources like nuts, eggs and cheeses. The 1st two weeks (induction) you were only allowed 20 net carbs a day (total carbs, minus fiber, minus sugar alcohol). After that, you typically could have 40 net per day, irrc. You could remain in the induction phase for longer, but it was for a limited time. He also allowed for a 'cheat day' every week or two. (Helped to stop a plateau).

He was very clear that it was a lifestyle change, not at all a fad diet.

My medical results were at their best when I adhered to the diet.

 

[MapleLeafFarmer]

In Canada next year Semaglutide (which is what is in Ozempic and I think is what people call a GLP-1 but I am no expert that's for sure) comes off patent protection.

Today on the news they said the 3 big generic companies here are in the works to get approval for their generic versions.

The reporter said pricing should likely come down to around $75 per month. Thinking when this happens it is going to become very popular.

(cut and past below)

Key Patent Expiry Timelines

• 2026 (Major Markets):
  Semaglutide patents start expiring in Canada (Jan 2026), India, and China, allowing generic manufacturers to enter these large populations.

• 2027 (US):
  The patent for Eli Lilly's older GLP-1 drug, Trulicity (dulaglutide), is set to expire.

• Early 2030s (US/EU):
  The core semaglutide compound patent, despite extensions, is expected to expire in the US and EU around 2031, allowing for biosimilar/generic competition later in the decade.
  

Impact of Expirations
Lower Costs: Generic semaglutide will significantly reduce treatment costs.
Increased Access: More affordable options will reach millions with diabetes and obesity.
Market Shift: Generics from Indian and other manufacturers will drive competition.

Specific Example: Canada
Novo Nordisk's primary semaglutide patent lapsed in Canada in 2025 (after failing to pay maintenance fees), with regulatory exclusivity expiring in early 2026, enabling immediate generic entry.

Broader Context
These expirations are a major event for the multi-billion dollar GLP-1 market, following years of high demand and high prices for branded drugs.

 

[rodneyn]

In Canada next year Semaglutide (which is what is in Ozempic and I think is what people call a GLP-1 but I am no expert that's for sure) comes off patent protection.

Today on the news they said the 3 big generic companies here are in the works to get approval for their generic versions.

The reporter said pricing should likely come down to around $75 per month. Thinking when this happens it is going to become very popular.

(cut and past below)

Key Patent Expiry Timelines

• 2026 (Major Markets):
  Semaglutide patents start expiring in Canada (Jan 2026), India, and China, allowing generic manufacturers to enter these large populations.
• 2027 (US):
  The patent for Eli Lilly's older GLP-1 drug, Trulicity (dulaglutide), is set to expire.
• Early 2030s (US/EU):
  The core semaglutide compound patent, despite extensions, is expected to expire in the US and EU around 2031, allowing for biosimilar/generic competition later in the decade.

Impact of Expirations
Lower Costs: Generic semaglutide will significantly reduce treatment costs.
Increased Access: More affordable options will reach millions with diabetes and obesity.
Market Shift: Generics from Indian and other manufacturers will drive competition.

Specific Example: Canada
Novo Nordisk's primary semaglutide patent lapsed in Canada in 2025 (after failing to pay maintenance fees), with regulatory exclusivity expiring in early 2026, enabling immediate generic entry.

Broader Context
These expirations are a major event for the multi-billion dollar GLP-1 market, following years of high demand and high prices for branded drugs.

I have tried all gl1-p drugs had opposite effects of gaining weight. Looks like 3-5% of the studied users for the drugs have the same issues. Losing weight old fashioned way not living to eat but eat to live. Novel concept.