When we transitioned from #2D to #2 LSD there were some problems with seals, but it was relatively minor. The switch to ULSD from #2 LSD in contrast, has caused a LOT of problems.
Some of the relevant facts are: Most refiners added virgin addatives for lubricity to LSD.... at least until they discovered used engine oil was cheaper and just as effective. Then we started seeing problems with seals, but again, it was minor. Then you go to ULSD and that stuff is DRY, it removed the elastomers (oils) from the seals and you often had seal leaks. This is MUCH more common on fuel systems operated extensively on LSD previously, hmmm, I wonder why? The EVIDENCE is the black line on the fuel filters run with red or green fuel, where does "black" come from? Used oil added to the fuel.
No amount of cetane improver will actually improve cetane for longer than a few days. Cetane is a light aeromatic and even in moderately cold temperatures it rapidly evaporates. The cetane of any fuel is determined mostly by the quality of the base stock and so a lesser extent by the refining process. Higher quality/more gentle = higher pump cetane. There are also two cetane measurements, as with gasoline, Cetane Number and Cetane Index (Motor and Research Octane). It is the AVERAGE of the Number and Index we need to be concerned with.
The EPA has estabilshed minimum standards for the fuels used for certification purposes, the EMA and SAE agree with those (higher) standards. The ASTM (led by Big Oil and Refiners) has steadfastly refused to amend their 40 cetane minimum "standard", eventhough everyone recognizes that the performance and emissions suffer greatly for it. The biggest factor in low cetane is increased crank-to-start times, cold smoke and soot production. Some loss of power is also reported with lower cetane fuels.