This is what Knipex has to say:
Left-handed tools are necessary when it is not possible for left-handers to use a “normal” tool, for example in the case of a breadknife, household scissors or a carpenter’s axe.
But pliers usually have a symmetrical design which means they can be operated without a problem in either your right or left hand.
In a few types of pliers there is a “preferred hand”, e.g. when adjusting the*Cobra

*water*pump pliers*or the pliers wrench.
They can also be adjusted easily by left-handers, however; different fingers are used here: whereas right-handers use the thumb on their right hand, left-handers use their index finger on their left hand to release the hinge bolt during adjustment.
While this may look a little different compared to the way a right-hander demonstrates or uses the pliers, left-handers get the hang of it very quickly.
