If you have the opportunity to start from scratch, then take it because everything else is a compromise.
1) orientation of the home = south to use available sunlight. Make sure there is nothing to the south to cast a shadow on you. Also make sure that open land to the south is not "open to development" so that maybe you get a supermarket there in the future...
2)Do a slab with built in radiant heat. Gets you the best temperature gradient from floor to ceiling and zones to independently control each major space. Also provides thermal mass for the sun to heat and store the heat, else you end up overheating the home when the sun is out. Consider a concrete wall inside the house for additional thermal mass for when the sun is low as in winter. It also makes for a quiet house.
3) Roof overhang on the south side to block summer sun during the hot part of the day
4) Most of the glazing (70-80%) on the south and low enough to allow slab to be heated. Little glazing to the North or west. Bedrooms or kitchen on east side for morning light
5) Use spray foam for air seal, if you can't afford it for full insulation value. Thin rigid insulation under siding on exterior to eliminate bridges. Then whatever you want to fill the space left.
6)Central wood stove with straight chimney in a central location. Radiant heating powered by hot water heater. You can lower the thermostat in the areas/zones heated effectively by the wood stove and raise them in areas you need warm that are not quite so effectively heated. Radiant will also cover spring and fall very effectively, so your burning season will effectively be shorter. If you install external solar collectors and tie them into the water heater, you will reduce fuel consumption when conditions are favorable, which is most of summer and part of winter. Having the water heater provides full time backup and cover when you need to be away. It also gives you flexibility regarding when to buy the solar collectors, provided you put the plumbing in so nothing has to be torn apart later.
7) Great quality windows and doors. Good storm doors help reduce air leakage
Thats my plan. In intend to use concrete block for exterior and interior walls with external rigid insulation including under the slab. Then foam sealed ceiling with sprayed in fiberglass on top. I'm doing a low pitched heavy duty metal roof with deep corrugations that one can walk on comfortably with about a 4 foot overhang on the south and sloping down to the North. North side will be earth bermed. Shop/garage will be on the west.