Can you run the load calculations to see what the deflection is of a 2x6 over 12' with your design psf?
Anecdote: when building carrying beams for my boat house roof system, I used triple-bolted pressure-treated 2x6s over a 12' span (they only support load near the ends, not in the middle). Anyway, when assembling the beams with through bolts, for which I had pre-drilled ahead of time, I noticed the single boards slightly sagged under their own weight when hanging over the 12' span. I had to wrestle them a bit to get the holes to line up. These were fresh/wet pressure treated boards, so they were much heavier than a dry 2x6 should be, but it impressed upon me how little stiffness a single 2x6 has over 12'. A sopping wet 2x6 would have about 3# per foot of loading from the liquid, which isn't a lot.
Another factor to consider is uplift. You should be able to start with the roofing metal and get a requirement for purlin spacing, then work your uplift loads down to fasteners for the purlins to the trusses, then trusses to header beams, etc. What I found with my boat house roof is that there was a manageable spacing for which I could properly attach purlins to rafters, and then rafters to headers with readily available screws and hurricane straps. I needed two #10 3-1/2" star drive screws for each purlin/rafter attachment (that's for a 2x4 purlin laid flat), and then each rafter needed about 600# of uplift resistance at it's seat (which I got by putting two hurricane straps at every rafter/header attachment).
When you start spacing out the rafters or trusses farther, it means each will carry more of the uplift load. And it could reach a point where you can't properly attach them to the headers with readily available hardware. Or you may run out of places to nail the straps on if you need more than one. Just something to consider.
How were you planning to attach the 2x6 purlins standing on edge to the trusses? When I have seen 2x6 and 2x8 purlins used, they were sitting between trusses supported by hanger brackets. Seemed like a lot of extra hassle.