It will likely stop in Alaska for 3 hours, take on fuel and have a small crew rest and swap out captains.
At a cost of about U$1.2 million + for a run like this (or more) it can p/u in central or Eastern N.A., make the one stop then hit just about anywhere in S.E. Asia or Eastern Russia.
It has been used to haul live pigs from Canada this route. Many times a Boeing 747-8f cargo makes similar run with livestock.
Coming from Philadelphia I would guess if livestock it is probably going to be horses going to Korea.
Shipping costs for plane alone is just over U$5 per pound so anything other than highly perishable (like livestock) or stuff really of high value in great demand usually doesn't make sense.