My brother and I are flipping an old house right now built in 1920's. We started with PEX right at the street with a new supply line to the house, then a 3/4" nice ball valve, then into a manifold. Everything for the kitchen, laundry, and bathrooms all come from this single manifold. In fact, the cold supply feeds right through the block, out to the hot water heater, then back from the water heater to the manifold. Really slick system and you can shut off each individual item right from the manifold. Also have the individual PEX shutoffs at each usage point, but it's redundant really.
This is the first time I've used a manifold of any type. If I were building my own home, I'd do this again for sure. Balanced water supply, etc.
We also ran the PEX where hard to access in the low points of the crawl space inside PVC as a conduit sleeve. This way, if the new home-owner ever has to replace a supply line to the kitchen per se, all they have to do is cut the old one, pull it out, and push the new one right back to the sink without ever crawling through a tight space or re-routing.