Sorry to hear Orezok. No experience with the drug, but it was suggested to me by vet (after it wasn't needed). A question. How recently did the symptoms begin, and related to that, how soon after her last Heartguard? The reason I ask, I had an older Basset Hound that took Heartguard his whole life, then started exhibiting inconsistent dementia symptoms after Heartguard once he hit 13 or so. First time it happened, I thought he might have had a stroke due to the symptoms, (weakness, difficulty walking, confusion, loss of appetite, hypersalivation, & fear of stepping over the threshold) and vet suggested Dog Alzheimer meds (I'm pretty sure it was Anipryl), but the way she said it, it seemed she was offering it more for my benefit than for Dusty's. Given that by the time I got an appointment for him to be seen (5 days) the symptoms were gone, his blood Chems were all good, & he was his happy self again, I declined. Symptoms would last 2-4 days accompanied by loss of appetite, excess drinking, agitation, panting, excess salivation, confusion & weakness. Not sure if it was a QC problem on Heartguard, or if he simply couldn't metabolize it the way he normally did. Didn't happen each month either, maybe 3 times in the last year or so. Confusion is one of the symptoms of Heartguard sensitivity, but that usually affects only herding dogs with a genetic sensitivity. Vet told me I was imagining things & there was no way a non-genetically sensitive dog could develop a sensitivity heartguard. But after everything we were told about human meds during covid, I now take all medical advice with a grain of salt. Hope Kali gets better & that the drug works for her.