My .02
Ptfe/others are designed to fill the minute gaps in threads which are installed tight. This joint is seeing (guess) 2000 psi, most likely pulsed, unless it's tight, it won't seal, or the sealant(whatever type, unless quick metal or similar) will eventually leak/be moved from between the surfaces. If you have room to remount and have a male and female JIC, I would go that way for longevity. You'll need ptfe or you preferred sealant on the threaded fittings to the valve block, but you'll be able to do them tight, then hold the male and tighten the female JIC. YMMV