"how do I design the wood floor to be at grade?"
My bad; my first impression was that the lower floor was smaller than the upper, which would've meant that the lower floor did NOT extend fully under the upper - now that I got my "cranius rectumus" under control, I see that isn't so.
Let me revise my answer to say this - looking at your West view, you will need a "basement wall" under the South end of the wood shop (and a DRAIN across that entire end, slightly lower than the slab) so hydraulic pressure doesn't eventually impact your lower floor's usable space

- if the outside slab is tied into that "basement" wall, then the ENTIRE upper floor can be framed the same way - one option would be to cast a ledge into the upper part of the "basement" wall for either wood or steel I beams to rest on - steel if you need to conserve depth on the upper floor frame and STILL support heavier weights near the big door.
That's why, knowing myself, I recommended an EXTENDED GABLE roof to cover the slab on that South side. That would let you load/unload on solid concrete and OUT of the rain. As an added bonus, the extended roof would also keep the shop a bit cooler on the 9 days a year it ain't RAINING
It sounds like you're wanting a SERIOUS wood shop, so make sure your upper floor can handle it - examples: My PM66 saw weighs around 500#, resting mainly on 4 casters (point loading) - my 6" powermatic jointer weighs about the same, built-in mobile base on THREE casters - 15" planer about 400# on 4 points, 12" Grizzly helical head jointer, just under 1000 lbs on 4 points; by now you probably get my "point" :laughing:
Sooo, I would run floor joists the SHORT way, probably on 16" centers - use 1-1/4" T&G ply over, then whatever SMOOTH floor covering that'll withstand heavy casters rolling around AND sweep up easily - the heavy ply will spread out all those POINT LOADS.
You'll still need to calculate dead load based on the ENTIRE weight of ALL MATERIALS used (frame, ply, covering, etc - easiest way is to take a 10'x10' section, count the weight of all joists in that area, add weight of 100 SF of ply, same with floor covering, then divide THAT total by 100 and add AT LEAST 10#, and that's your minimum dead load PSF. If THAT # can't be supported in span calculator with those joists, increase joist size (or re-figure with 12" centers instead of 16, etc...)
Live load includes you and friends, machinery, wood racks, etc - I'm not always sure how to approach that, other than "overbuild and pray"

but I'm pretty sure that you will need to involve an architect in this project anyway; if so, make a list of ALL POSSIBLE stuff you want on that second floor, you're gonna PAY 'EM ANYWAY, one way or another
'Bout all I got for now, gonna spend today recovering from about 80 trips up and down 3 ladders adding
flashing on my shop roof that the roofers apparently didn't think necessary (hopefully it'll stop the need for a tarp INSIDE my studio to keep $25k of music/sound equipment DRY

... Steve