I lined the roof with 15# felt, then I laid 2x4 purlins.I figure the 2x's give the screws a little more bite. The boys at the Metal Depot recommended screwing the panels every 30". They recommend a screw every 20" where the panels lap. I wouldn't go directly over the plywood or old roof, the purlins give you an air gap that should let condensation evaporate and vent out of the ends. That's just my opinion, I'm not an expert at this by no means. One mistake I might have made, I used pressure treated lumber. Pressure treated lumber is now treated with ACQ, whatever that means. I might have a problem in the future from having the galvalum panels in proximity to the treated wood. I extended the roof over the porch, on PT lumber, so I ought to be able to watch for corrosion. I'll let everybody know how long it takes for holes to start appearing.