I know why there have been so many responses to this thread: drilling holes in thick metal is the biggest hassle of all for us amature fabricators. Now that said, I think all the methods I have used have been covered. Twist drills up to 1-inch, bi-metal hole saws (2-inch is my record in 1/2" A36 steel), plasma cutter with aluminum templates, milled holes (on a friend's Bridgeport mill), lathe with 4-jaw chuck (has that one been mentioned?), and my favorite: $1/hole on a
50T hydraulic punch at a machinist. My next tool may be a 40T ironworker....they can be had for $2500 new. Punches and dies are extra. Like others, my drill press is crappy, a 16.5" Delta floor model purchased new more than 25y ago. 250 RPM is slowest speed and the bearings complain big time when doing big holes. Is it time for a "good" drill press? BTW, if you ever get that plasma cutter (sweeeet), the oxy-acetylene torch will be relegated to the rare heating and brazing tasks.