First I'll try to answer the question as opposed to making other suggestions. 2-4D works BEST when applied to an actively growing, post germination plant. It does have some residual value once in the soil, giving it SOME (very limited) pre-emergent value, but that requires quite heavy application rates to be effective. As mentioned, it is a treatment for BROADLEAF weeds only. It won't touch grasses unless you over-apply. Then it can (and will) burn grass. It's HIGHLY recommended that you NEVER over-apply ANY pesticide, deliberately or accidentally.
I've had good results applying 2-4D in early spring, just as the problem weeds begin to emerge. Ideally, you want to eliminate weeds BEFORE they have the opportunity to re-seed themselves. However, I have treated pastures with a light dose of 2-4D in the fall, then again in early spring, after last years crop of weed seed has re-emerged. It's always been my experience that 2 applications is better than one. Applying at overly high rates to get a complete kill in one application may be harmfull to any desired crop/grass you have.
Grazon was mentioned already. It's a better alternative, but is a restricted use chemical in some states, making it unavailable to those areas unless you have proper certification.