You can, but if you don't need the extra hauling/towing capacity why would you want to? Worse gas mileage, higher insurance, registration and repair costs and a worse ride. And just because it's a 25-3500 doesn't mean it doesn't have a short bed.
I wouldn't consider a 1500 to be a "car with a tiny bed on the back"...Maverick or a Santa Cruze yeah, but the 1500 is still a full size truck.
My counterpoints to this, whether you consider them valid or not, are that 1500s are basically cars with tiny beds. If I want to drive a car, I'll drive one. If I need a pickup, I'll take it instead.
Blanket statements like worse mileage, higher insurance and registration, and repair costs, doesn't apply in my case.
If I towed even 25% of what I pull with the 3500 Cummins with the 1500 the mileage would be worse, much worse. Actually, there's only about a 40% difference as it is and that's without towing with the 1500.
In my case the 14,000 GVWR 3500 costs less in insurance than does the 1500. Granted, the 3500 is a '17 and the 1500 is a '21. If memory serves me, the 3500 is $5 more per year in registration. Again, age can factor in.
Repair costs? Okay, oil changes cost more on the 3500 because it holds more oil, but it can also go longer between changes. And with regular maintenance the Cummins should go about 500,000 miles. That's more than any 1500 engine I know of, not even counting the notoriously dismal Ecodiesel.
Lastly, as far as ride quality goes, yes the car with a tiny bed does does ride better than a real pickup. On the other hand, I stopped going to the store after dark to buy five cases of water since I got tired of having to adjust the headlights for the drive home.
Had a '14 1500 V6 for many years, and it got good mileage, did everything a car should, but it was just that - a car with a tiny bed and
very boring. My current 1500 is much more fun to drive, but it's still a car, and with an even tinier bed.