it doesn't matter what the comment was, or the context is, I often use the meaningless response ... That Explains A Lot - people have no idea what to think, they get confused, and I walk away and chuckle
I make random comments like Never Doubt Me, or That's Part Of Your Charm
People ask How are you doing ? I say I'm Being Good (not even an answer)
I often ask people Are You Behaving ? ... especially good for when I was doing Community Corrections supervision
I used to start supervision conversations with criminals, by simply stating What is all this stuff that I've heard about you? (this, when I actually know nothing) ... they generally opened up and told me about a recent arrest, fight, party etc